Power BI Desktop has rendering issues on systems with multiple monitors. For example:
Note the black areas where the ribbon, left side icons and status bar should be. The large black square in the middle is the Get data / What's new intro dialog.
This issue or ones very similar have been noted before:
The problem appears to have something to do with having multiple monitors with different resolutions/scaling settings. Setting all of my displays to the same scale setting did not work in my case (and wouldn't be acceptable any way). The only work-around for me is to either set my latop screen to be the main display or to drag the power bi windows to the the laptop screen and then back to the display that I actually need to use.